Solvent-free and room temperature synthesis of 3-arylquinolines from different anilines and styrene oxide in the presence of Al2O3/MeSO3H

Hashem Sharghi; Mahdi Aberi; Mohsen Khataminejad; Pezhman Shiri

doi:10.3762/bjoc.13.193

Solvent-free and room temperature synthesis of 3-arylquinolines from different anilines and styrene oxide in the presence of Al₂O₃/MeSO₃H

Beilstein J Org Chem. 2017 Sep 20:13:1977-1981. doi: 10.3762/bjoc.13.193. eCollection 2017.

Authors

Hashem Sharghi¹, Mahdi Aberi¹, Mohsen Khataminejad¹, Pezhman Shiri¹

Affiliation

¹ Department of Chemistry, Shiraz University, Shiraz, 71454, I. R. Iran, Tel.: +98 711 2284822.

Abstract

A highly efficient, simple and environmentally friendly synthesis of 3-arylquinolines has been developed in the presence of Al₂O₃/MeSO₃H via one-pot reaction of anilines and styrene oxide. This methodology provides very rapid access to 3-arylquinolines in good to excellent yields under solvent-free conditions at room temperature in air.

Keywords: 3-arylquinolines; Al2O3; MeSO3H; one-pot reaction; solvent-free conditions.