Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions

Caries Res. 2017;51(6):590-595. doi: 10.1159/000479828. Epub 2017 Oct 24.

Abstract

The aim of this study was to analyze the association between BMP2 (rs1884302) and DLX3 (rs2278163) gene polymorphisms and dental caries in primary and permanent dentitions. A total of 914 subjects were genotyped by the TaqMan methods: 176 caries-free children (with Decayed/Missing/Filled Teeth, DMFT = 0), 542 patients with dental caries in permanent dentition (DMFT ≥1), 83 caries-free children with primary teeth (with decayed/missing/filled teeth, dmft = 0), and 113 children with early childhood caries (ECC, dmft ≥1). There were no significant differences in allele/genotype frequencies between patients with caries in permanent dentition/ECC and caries-free children or between patients with very low (DMFT = 0-2), low (DMFT = 3-5), moderate (DMFT = 6-8), or high (DMFT ≥9) caries experience. Variability in BMP2 and DLX3 was not associated with caries in the Czech population.

Keywords: BMP2; Case-control study; DLX3; Dental caries; Gene polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles
  • Bone Morphogenetic Protein 2 / genetics*
  • Child
  • Child, Preschool
  • Czech Republic
  • DMF Index
  • Dental Caries / genetics*
  • Dentition, Permanent
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Homeodomain Proteins / genetics*
  • Humans
  • Male
  • Polymorphism, Single Nucleotide*
  • Severity of Illness Index
  • Tooth, Deciduous
  • Transcription Factors / genetics*

Substances

  • BMP2 protein, human
  • Bone Morphogenetic Protein 2
  • Distal-less homeobox proteins
  • Homeodomain Proteins
  • Transcription Factors