Abstract
Cocrystallization of nifedipine (NFD) and isonicotinamide (INA) resulted in two monotropic cocrystal polymorphs. The thermodynamically more stable polymorph presents superior photostability compared to the other. Cocrystallization can be an efficient approach to address the stability deficit of dihydropyridine drugs.
MeSH terms
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Calcium Channel Blockers / chemistry*
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Crystallization
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Dihydropyridines / chemistry*
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Molecular Conformation
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Niacinamide / chemistry*
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Nifedipine / chemistry*
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Oxidation-Reduction
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Photochemical Processes
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Thermodynamics
Substances
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Calcium Channel Blockers
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Dihydropyridines
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Niacinamide
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isonicotinamide
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1,4-dihydropyridine
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Nifedipine