Small size mesoporous organosilica nanorods with different aspect ratios: Synthesis and cellular uptake

Yanjiao Li; Wenwen Guo; Xiaodan Su; Lin Ou-Yang; Meng Dang; Jun Tao; Guangming Lu; Zhaogang Teng

doi:10.1016/j.jcis.2017.10.006

Small size mesoporous organosilica nanorods with different aspect ratios: Synthesis and cellular uptake

J Colloid Interface Sci. 2018 Feb 15:512:134-140. doi: 10.1016/j.jcis.2017.10.006. Epub 2017 Oct 4.

Authors

Yanjiao Li¹, Wenwen Guo², Xiaodan Su³, Lin Ou-Yang⁴, Meng Dang³, Jun Tao³, Guangming Lu⁵, Zhaogang Teng⁶

Affiliations

¹ Department of Medical Imaging of Southeast Hospital, Medical College of Xiamen University, Zhangzhou 363000, Fujian, PR China.
² School of Medicine, Southeast University, Nanjing 210009, Jiangsu, PR China.
³ Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210046, Jiangsu, PR China.
⁴ Department of Medical Imaging of Southeast Hospital, Medical College of Xiamen University, Zhangzhou 363000, Fujian, PR China. Electronic address: ddcqzg@126.com.
⁵ Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, Jiangsu, PR China. Electronic address: cjr.luguangming@vip.163.com.
⁶ Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, Jiangsu, PR China. Electronic address: tzg@fudan.edu.cn.

PMID: 29055795
DOI: 10.1016/j.jcis.2017.10.006

Abstract

In the work, small size thioether-bridged mesoporous organosilica nanorod (MONRs) are successfully synthesized using cetyltrimethylammonium bromide (CTAB) as structure-directing agent and bis[3-(triethoxysilyl)propyl]tetrasulfide (TETS) and tetraethoxysilane (TEOS) as co-precursors. The MONRs have tunable aspect ratios of 2, 3, and 4 (denoted as MONRs-2, MONRs-3, and MONRs-4), small and controllable lengths (75-310nm), high surface area (570-870cm²g^-1), uniform mesopores (2.4-2.6nm), large pore volume (0.34cm³g^-1), and excellent biocompatibility. The uptake of the MONRs by multidrug resistant human breast cancer MDR-MCF-7 cells is related to their aspect ratios. The MONRs-3 shows a faster and higher cellular internalization compared to the MONRs-4 and MONRs-2, respectively. Thanks to the high cellular uptake, doxorubicin (DOX) loaded MONRs-3 show obviously improved chemotherapeutic effect on MDR-MCF-7 cancer cells. It is expected that the MONRs provide a useful platform for drug delivery and therapeutics.

Keywords: Cellular uptake; Drug delivery; Mesoporous organosilica; Nanorods; Small size.

MeSH terms

Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / pharmacology*
Breast Neoplasms / drug therapy
Breast Neoplasms / metabolism
Breast Neoplasms / pathology*
Doxorubicin / chemistry
Doxorubicin / pharmacology*
Drug Carriers / chemistry*
Drug Delivery Systems*
Drug Resistance, Multiple / drug effects
Drug Resistance, Neoplasm / drug effects
Female
Humans
Nanotubes / chemistry*
Organosilicon Compounds / chemistry*
Porosity
Tumor Cells, Cultured

Substances

Antibiotics, Antineoplastic
Drug Carriers
Organosilicon Compounds
Doxorubicin