Transforming Lipoxygenases: PE-Specific Enzymes in Disguise

Ling F Ye; Brent R Stockwell

doi:10.1016/j.cell.2017.10.006

Transforming Lipoxygenases: PE-Specific Enzymes in Disguise

Cell. 2017 Oct 19;171(3):501-502. doi: 10.1016/j.cell.2017.10.006.

Authors

Ling F Ye¹, Brent R Stockwell²

Affiliations

¹ Department of Biological Sciences, Columbia University, 550 West 120(th) Street, MC4846, New York, NY 10027, USA.
² Department of Biological Sciences, Columbia University, 550 West 120(th) Street, MC4846, New York, NY 10027, USA; Department of Chemistry, Columbia University, 550 West 120(th) Street, MC4846, New York, NY 10027, USA. Electronic address: bstockwell@columbia.edu.

Abstract

In this issue of Cell, Wenzel et al. solve a long-standing mystery regarding how damage to cell membranes occurs during ferroptosis, an iron-dependent form of regulated cell death. They found that lipoxygenases are like Transformer toys, being converted from one enzyme type to another in the presence of the protein PEBP1.

Publication types

Comment

MeSH terms

Apoptosis
Cell Death
Lipids
Lipoxygenase*
Lipoxygenases*

Substances

Lipids
Lipoxygenases
Lipoxygenase

Abstract

Publication types

MeSH terms

Substances

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