[Two new triterpenoid acids from Uighur medicine Fomes officinalis]

Jian-Xin Han; Tao Yuan

doi:10.19540/j.cnki.cjcmm.20170224.021

[Two new triterpenoid acids from Uighur medicine Fomes officinalis]

Zhongguo Zhong Yao Za Zhi. 2017 Apr;42(7):1225-1228. doi: 10.19540/j.cnki.cjcmm.20170224.021.

[Article in Chinese]

Authors

Jian-Xin Han^{1

2}, Tao Yuan¹

Affiliations

¹ The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
² University of Chinese Academy of Sciences, Beijing 100049, China.

PMID: 29052377
DOI: 10.19540/j.cnki.cjcmm.20170224.021

Abstract

Two new lanostane triterpenoid acids, 12β, 15α-dihydroxy-24-methyl-3,23-dioxo-lanosta-7,9(11)-dien-26-oic acid (1), and 3α, 12β-dihydroxy-24-methyl-7,23-dioxo-lanosta-8-en-26-oic acid (2), were isolated from the methanolic extract of Uighur medicine Fomes officinalis. Their structures were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HR-MS). Anti-inflammatory and cytotoxicity assays revealed that both compound 1 and 2 show no inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW264.7 cells, and no cytotoxicity activities against HepG2 cells.

Keywords: Fomes officinalis; Uighur medicine; anti-inflammatory; cytotoxicity; triterpenoid acid.

MeSH terms

Animals
Coriolaceae / chemistry*
Hep G2 Cells
Humans
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nitric Oxide / metabolism
RAW 264.7 Cells
Triterpenes / isolation & purification*

Substances

Triterpenes
Nitric Oxide