Elimination of different leukaemia subtypes using novel CD89-specific human cytolytic fusion proteins

Gerrit Gresch; Lea Schenke; Radoslav Mladenov; Stefan Zwirner; Christian Cremer; Judith Niesen; Elena Grieger; Tim Brümmendorf; Edgar Jost; Rainer Fischer; Bernhard Stockmeyer; Stefan Barth; Thomas Nachreiner; Christoph Stein

doi:10.1111/bjh.14971

Elimination of different leukaemia subtypes using novel CD89-specific human cytolytic fusion proteins

Br J Haematol. 2018 Oct;183(2):313-317. doi: 10.1111/bjh.14971. Epub 2017 Oct 19.

Authors

Gerrit Gresch^{1

2}, Lea Schenke^{1

2}, Radoslav Mladenov¹, Stefan Zwirner¹, Christian Cremer², Judith Niesen¹, Elena Grieger^{1

2}, Tim Brümmendorf³, Edgar Jost³, Rainer Fischer¹, Bernhard Stockmeyer⁴, Stefan Barth^{1

2

5}, Thomas Nachreiner², Christoph Stein^{1

2}

Affiliations

¹ Department of Immunotherapy, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany.
² Institute for Applied Medical Engineering, RWTH Aachen University Hospital, Aachen, Germany.
³ Department of Haematology and Oncology (Internal Medicine IV), RWTH Aachen University Hospital, Aachen, Germany.
⁴ Department of Internal Medicine 5, Haematology/Oncology, University of Erlangen-Nuremberg, Erlangen, Germany.
⁵ South African Research Chair in Cancer Biotechnology, Institute of Infectious Disease and Molecular Medicine (IDM), Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

PMID: 29048126
DOI: 10.1111/bjh.14971

No abstract available

Keywords: angiogenin (Ang); human cytolytic fusion proteins (hCFP); leukaemia; microtubule-associated protein tau (MapTau); single-chain Fragment variable (scFv).

MeSH terms

Antigens, CD / immunology*
Apoptosis / drug effects
Humans
Immunotherapy / methods*
Immunotoxins / pharmacology
Immunotoxins / therapeutic use*
Leukemia, Myeloid / pathology
Leukemia, Myeloid / therapy*
Receptors, Fc / immunology*
Recombinant Fusion Proteins / pharmacology
Recombinant Fusion Proteins / therapeutic use
Tumor Cells, Cultured

Substances

Antigens, CD
Fc(alpha) receptor
Immunotoxins
Receptors, Fc
Recombinant Fusion Proteins