CD14-New Tricks of an Old Acquaintance

Florian I Schmidt; Eicke Latz

doi:10.1016/j.immuni.2017.10.003

CD14-New Tricks of an Old Acquaintance

Immunity. 2017 Oct 17;47(4):606-608. doi: 10.1016/j.immuni.2017.10.003.

Authors

Florian I Schmidt¹, Eicke Latz²

Affiliations

¹ Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.
² Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA; German Center for Neurodegenerative Diseases, Bonn, Germany. Electronic address: eicke.latz@uni-bonn.de.

PMID: 29045891
DOI: 10.1016/j.immuni.2017.10.003

Abstract

Zanoni et al. (2017) show that the LPS receptor CD14 promotes internalization of oxidized phospholipids, a hallmark of dying cells, triggering hyperactivation of dendritic cells and macrophages. Their findings reveal CD14 as a regulator of responses to infection and damage, relaying context-dependent signals that determine inflammatory cell fate decisions.

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MeSH terms

Friends
Inflammasomes*
Lipopolysaccharide Receptors
Lipopolysaccharides*
Phagocytes

Substances

Inflammasomes
Lipopolysaccharide Receptors
Lipopolysaccharides