Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers

Org Biomol Chem. 2017 Oct 31;15(42):9008-9017. doi: 10.1039/c7ob02270k.

Abstract

In the present study we describe the synthesis, photophysical properties and the photoinactivation performance against representative microorganisms of two families of cationic dendrimeric phthalocyanines as potential photosensitisers. Four charged dendrimeric compounds varying in their degree of ionicity (4 or 8 positive charges) and the coordinating metal (zinc or ruthenium) are compared and assessed as potential photosensitising agents in terms of their antimicrobial activity.

MeSH terms

  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects*
  • Cations / chemical synthesis
  • Cations / chemistry
  • Cations / pharmacology
  • Dendrimers / chemical synthesis
  • Dendrimers / chemistry
  • Dendrimers / pharmacology*
  • Dose-Response Relationship, Drug
  • Escherichia coli / drug effects*
  • Indoles / chemical synthesis
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Isoindoles
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Photosensitizing Agents / chemical synthesis
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Cations
  • Dendrimers
  • Indoles
  • Isoindoles
  • Photosensitizing Agents
  • phthalocyanine