The spectroscopic characteristics, continuous-wave (CW) and mode-locking laser performances of Tm,Y:CaF2 disordered crystal were studied. A maximum CW output power of 586 mW was obtained with a slope efficiency of 26%. The Tm,Y:CaF2 mode-locked laser could operate in two states: single-wavelength mode locking or dual-wavelength synchronous mode locking. The single-wavelength mode-locked laser generated pulses with pulse duration of 22 ps, repetition rate of 99 MHz, and pulse energy of 1.15 nJ at 1887 nm. Alternatively, the laser could also be mode-locked simultaneously at 1880.7 nm and 1889.0 nm wavelengths. The beating modulation in autocorrelation trace shows that the dual-wavelength pulses were temporally synchronous.