We report on a room-temperature Kerr-lens mode-locked Cr:ZnSe femtosecond laser operating at around 2.4 μm emission wavelength. Self-starting nearly transform-limited pulse trains with a minimum duration of 47 fs, corresponding to six optical cycles, and average output power of 0.25 W are obtained with repetition frequencies in the range from 140 to 300 MHz. The femtosecond pulse train is characterized by high-spectral purity and low time jitter.