Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis

J Laryngol Otol. 2017 Nov;131(11):997-1001. doi: 10.1017/S0022215117002110. Epub 2017 Oct 17.

Abstract

Background: Allergic rhinitis is strongly associated with the presence of house dust mites. This study investigated the long-term effects of allergen-specific immunotherapy. Allergen-specific immunotherapy was applied over three years. The study was based on a 10-year follow up of patients with allergic rhinitis.

Methods: The study was conducted between 2001 and 2015. Skin prick test results and symptom scores were evaluated before (26 patients) and after 3 years (20 patients) of allergen-specific immunotherapy (using data from a previously published study), and 10 years after allergen-specific immunotherapy had ended (20 of 26 patients).

Results: The symptom scores before allergen-specific immunotherapy were significantly higher than those obtained after 3 years of allergen-specific immunotherapy and 10 years after allergen-specific immunotherapy (p 0.0175).

Conclusion: Subcutaneous immunotherapy is an effective treatment for house dust mite induced allergic rhinitis.

Keywords: Allergy; Immunotherapy; Subcutaneous Immunotherapy.

MeSH terms

  • Adult
  • Animals
  • Desensitization, Immunologic / methods*
  • Humans
  • Injections, Subcutaneous
  • Male
  • Pyroglyphidae / immunology*
  • Rhinitis, Allergic / etiology
  • Rhinitis, Allergic / immunology
  • Rhinitis, Allergic / therapy*
  • Skin Tests
  • Treatment Outcome
  • Young Adult