Synthesis of BSA-Coated BiOI@Bi2 S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor

Zhao Guo; Shuang Zhu; Yuan Yong; Xiao Zhang; Xinghua Dong; Jiangfeng Du; Jiani Xie; Qing Wang; Zhanjun Gu; Yuliang Zhao

doi:10.1002/adma.201704136

Synthesis of BSA-Coated BiOI@Bi₂ S₃ Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor

Adv Mater. 2017 Nov;29(44). doi: 10.1002/adma.201704136. Epub 2017 Oct 16.

Authors

Zhao Guo^{1

2}, Shuang Zhu¹, Yuan Yong^{1

3}, Xiao Zhang^{1

2

4}, Xinghua Dong^{1

2}, Jiangfeng Du^{1

5}, Jiani Xie^{1

2}, Qing Wang⁶, Zhanjun Gu^{1

2}, Yuliang Zhao^{1

2

4}

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
² College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
³ College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu, Sichuan, 610041, China.
⁴ CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, 100190, China.
⁵ Department of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
⁶ School of Material Science and Engineering, Institute of Nano Engineering, Shandong University of Science and Technology, Qingdao, Shandong, 266590, China.

PMID: 29035426
DOI: 10.1002/adma.201704136

Abstract

Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. Here, BiOI@Bi₂ S₃ @BSA (bovine serum albumin) semiconductor heterojunction nanoparticles (SHNPs) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (CT/PA) bioimaging are reported. On the one hand, SHNPs possess strong X-ray attenuation capability since they contain high-Z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement. On the other hand, as a semiconductor, the as-prepared SHNPs offer an extra approach for reactive oxygen species generation based on electron-hole pair under the irradiation of X-ray through the photodynamic therapy process. This X-ray excited photodynamic therapy obviously has better penetration depth in bio-tissue. What's more, the SHNPs also possess well photothermal conversion efficiency for photothermal therapy, because Bi₂ S₃ is a thin band semiconductor with strong near-infrared absorption that can cause local overheat. In vivo tumor ablation studies show that synergistic radio/photodynamic/photothermal therapy achieves more significant therapeutic effect than any single treatment. In addition, with the strong X-ray attenuation and high near-infrared absorption, the as-obtained SHNPs can also be applied as a multimodal contrast agent in CT/PA imaging.

Keywords: bismuth oxyiodide; photodynamic therapy; photothermal therapy; radiotherapy; semiconductors.