Association of -319 C/T and +49 A/G polymorphisms of CTLA-4 gene in patients with hepatitis C virus infection
Med Clin (Barc). 2018 Apr 13;150(7):251-256.
doi: 10.1016/j.medcli.2017.06.074.
Epub 2017 Oct 14.
[Article in
English,
Spanish]
Authors
Moisés Enciso-Vargas
1
, Bertha Ruíz-Madrigal
1
, José Francisco Muñoz-Valle
2
, Omar Yair Morales-Balderas
1
, Zamira Helena Hernández-Nazara
3
, Erika Martínez-López
4
, Carlos Dávalos-Cobian
5
, Jorge Ramón Padilla-Gutiérrez
2
, José Rodrigo Torres-Baranda
6
, José Alfredo Domínguez-Rosales
3
, Montserrat Maldonado-González
7
Affiliations
- 1 Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México; Programa de Doctorado en Ciencias Biomédicas (Inmunología), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
- 2 Programa de Doctorado en Ciencias Biomédicas (Inmunología), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México; Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
- 3 Instituto de Investigación en Enfermedades Crónico Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara , Jalisco, México.
- 4 Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio Alcalde, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
- 5 Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara , Jalisco, México.
- 6 Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
- 7 Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México; Programa de Doctorado en Ciencias Biomédicas (Inmunología), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México. Electronic address: montserratmaldonado@yahoo.com.mx.
Abstract
Introduction and objective:
Molecular changes in the CTLA-4 gene can modify the ability to control T lymphocyte proliferation, and promote the persistence or elimination of the hepatitis C virus (HCV). We aimed to investigate the frequency and association of -319 C/T and +49 A/G polymorphism in the CTLA-4 gene in patients infected with HCV.
Methods:
The CTLA-4 gene polymorphisms (-319 C/T in the promoter region, and +49 A/G in exon 1) were analysed by T-ARMS-PCR in 420 individuals, including 205 chronic HCV infected patients and 215 healthy subjects.
Results:
We found a positive association of +49G allele with HCV infection (OR 1.48; 95% CI 1.09-2.02; p=.02), and with males (OR 1.80; 95% CI 1.16-2.79; p=.02), both in chronic disease (without cirrhosis). Also, significant differences in +49 A/G genotypes distribution between HCV infected patients and healthy subjects were shown in a dominant genetic model (GG+GA versus AA; OR 1.57; 95% CI 1.05-2.33; p=.04). No significant differences were observed in the -319 C/T polymorphism between HCV infected patients and healthy subjects. Moreover, -319C/+49G haplotype confers susceptibility to HCV genotype 3 infection (OR 10.68; 95% CI 1.17-96.97; p=.04).
Conclusions:
The +49G allele confers susceptibility to HCV infection and with male gender, both in chronic disease. In addition, the -319C/+49G haplotype confers susceptibility to HCV genotype 3 infection. Our results support an important role of the -319 C/T and +49 A/G polymorphisms in HCV infection.
Keywords:
CTLA-4; Hepatitis C virus; Polimorfismo de un solo nucleótido; Single nucleotide polymorphisms.
Copyright © 2017 Elsevier España, S.L.U. All rights reserved.
MeSH terms
-
Adult
-
Aged
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Aged, 80 and over
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CTLA-4 Antigen / genetics*
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Cross-Sectional Studies
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Female
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Hepatitis C, Chronic / genetics*
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Humans
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Male
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Middle Aged
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Polymorphism, Single Nucleotide*
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Young Adult
Substances
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CTLA-4 Antigen
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CTLA4 protein, human