New Polymorph Form of Dexamethasone Acetate

J Pharm Sci. 2018 Feb;107(2):672-681. doi: 10.1016/j.xphs.2017.10.001. Epub 2017 Oct 12.

Abstract

A new monohydrated polymorph of dexamethasone acetate was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal and polycrystal X-ray diffraction, solid state nuclear magnetic resonance, infrared spectroscopy. A Hirshfeld surface analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. This new polymorph form appeared because of self-arrangement via classical hydrogen bonds around the water molecule.

Keywords: X-ray polycrystal diffractometry and C-13 CPMAS NMR; crystal structure; molecular modeling; polymorph.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallization / methods
  • Crystallography, X-Ray / methods
  • Dexamethasone / analogs & derivatives*
  • Dexamethasone / chemistry
  • Hydrogen Bonding
  • Magnetic Resonance Spectroscopy / methods
  • Water / chemistry
  • X-Ray Diffraction / methods

Substances

  • Water
  • Dexamethasone
  • dexamethasone acetate