Gene polymorphisms of DISC1 is associated with schizophrenia: Evidence from a meta-analysis

Hong-Yu Wang; Yong Liu; Jun-Wei Yan; Xing-Long Hu; Dao-Min Zhu; Xiao-Tong Xu; Xiao-Si Li

doi:10.1016/j.pnpbp.2017.10.008

Gene polymorphisms of DISC1 is associated with schizophrenia: Evidence from a meta-analysis

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2:81:64-73. doi: 10.1016/j.pnpbp.2017.10.008. Epub 2017 Oct 12.

Authors

Hong-Yu Wang¹, Yong Liu¹, Jun-Wei Yan², Xing-Long Hu¹, Dao-Min Zhu¹, Xiao-Tong Xu¹, Xiao-Si Li³

Affiliations

¹ Anhui Mental Health Center, Hefei, Anhui, China; The Fourth People's Hospital of Hefei, Hefei, Anhui, China.
² Epidemiological Research Office, Anhui Chest Hospital (Anhui TB control center), Hefei, Anhui, China.
³ Anhui Mental Health Center, Hefei, Anhui, China; The Fourth People's Hospital of Hefei, Hefei, Anhui, China. Electronic address: dodotoo8828@126.com.

PMID: 29031911
DOI: 10.1016/j.pnpbp.2017.10.008

Abstract

Background: Previous studies suggest an association between Disrupted in schizophrenia 1 (DISC1) polymorphisms and schizophrenia (SCZ). However, the available data are often inconsistent, regarding the difference in sample size, ethnicity, genotyping method, etc. Thus, we carried out a meta-analysis to determine whether DISC1 polymorphisms contributed susceptibility to SCZ.

Methods: A methodical literature review was operated using the English and Chinese core electronic databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to determine the correlation between DISC1 gene polymorphisms and SCZ susceptibility. Subgroup analyses were carried out by stratification of ethnicity. P values were Bonferroni adjusted to account for multiple testing. Publication bias was evaluated by funnel plots, Egger's test and the trim and fill method.

Results: Meta-analyses results suggested that DISC1 polymorphisms (rs821616 and rs821597) increased SCZ risk in overall populations. In subgroups of ethnicity, DISC1 polymorphisms (rs821616 and rs821597) was associated with susceptibility to SCZ among the Chinese population (for rs821616: TT+AT vs. AA: OR=1.338, 95% CI=1.124-1.592, P=0.001; T vs. A: OR=1.300, 95% CI=1.124-1.504, P<0.000; for rs821597: AA+AG vs. GG: OR=1.508, 95% CI=1.268-1.794, P<0.001; A vs. G: OR=1.345, 95% CI=1.184-1.527, P<0.001). A positive correlation was also observed between the single marker rs821616 and SCZ among the Japanese population in the recessive model (TT vs. AT+AA: OR=1.524, 95% CI=1.185-1.959, P=0.001). There was no significant relationship between other DISC1 polymorphisms (rs3738401, rs2273890, rs3738398, rs3738402, rs2492367, rs843979, rs3737597, rs4658971, rs1538979, rs1000731 and rs3738399) and SCZ.

Conclusions: DISC1 polymorphisms increased a risk of SCZ, especially in the Chinese population. In order to further corroborate our findings, large well-designed epidemiological studies are needed.

Keywords: DISC1; Disrupted-in-Schizophrenia-1; Gene polymorphisms; SCZ; Schizophrenia.

Publication types

Meta-Analysis
Review

MeSH terms

Asian People / genetics
Genetic Predisposition to Disease*
Humans
Nerve Tissue Proteins / genetics*
Polymorphism, Single Nucleotide*
Schizophrenia / ethnology
Schizophrenia / genetics*

Substances

DISC1 protein, human
Nerve Tissue Proteins