Abstract
Two types of exogenous K channel were identified in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting cell line HIT T15. One of these was the ATP-regulated K channel (G channel) as evidenced by its conductance and inhibition by tolbutamide. The other resembled the Ca-activated K channel from beta-cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium / pharmacology
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Cell Line
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Cell Membrane / drug effects
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Cell Membrane / physiology
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Female
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Insulin / metabolism
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Insulin Secretion
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Islets of Langerhans / metabolism
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Membrane Potentials / drug effects
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Oocytes / physiology*
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Poly A / genetics*
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Potassium Channels / physiology*
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Protein Biosynthesis
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RNA, Messenger / genetics*
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Tolbutamide / pharmacology
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Xenopus laevis
Substances
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Insulin
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Potassium Channels
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RNA, Messenger
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Poly A
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Tolbutamide
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Calcium