Review: The relationship of hemoglobin A1c to postoperative surgical risk with an emphasis on joint replacement surgery

J Diabetes Complications. 2017 Dec;31(12):1710-1718. doi: 10.1016/j.jdiacomp.2017.08.016. Epub 2017 Sep 7.

Abstract

Patients with diabetes mellitus are known to have a high risk of postoperative complications, including infections, impaired wound healing, cardiovascular events, venous thromboembolism, and mortality. Because hyperglycemia has been thought to mediate this risk, there is a clinical propensity for improving glycemic control, as assessed by hemoglobin A1c (HbA1c) level, prior to proceeding with elective surgery, particularly joint replacement surgery. However, it is not established whether chronic poor glycemic control, indicated by elevated HbA1c levels, predicts increased risk of postoperative complications. The benefit of improving glycemic control must be weighed against risks of delaying necessary elective surgery, such as joint replacement surgery, which risks may include negative impact on long-term glycemic control. Thus, we review the current evidence to determine the relationship between HbA1c and postoperative surgical risk, especially on joint replacement surgery.

Keywords: Diabetes; Hemoglobin A1c; Joint surgery; Postoperative; Surgical risk.

Publication types

  • Review

MeSH terms

  • Arthroplasty, Replacement / adverse effects*
  • Diabetes Complications / blood
  • Diabetes Complications / surgery*
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / therapy*
  • Elective Surgical Procedures / adverse effects
  • Evidence-Based Medicine*
  • Glycated Hemoglobin / analysis*
  • Humans
  • Hyperglycemia / prevention & control
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology*
  • Postoperative Complications / prevention & control
  • Risk
  • Wound Healing

Substances

  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human