Polychlorinated dibenzo-p-dioxins and dibenzofurans levels in piglet liver with various diseases

Int J Exp Pathol. 2017 Aug;98(4):214-220. doi: 10.1111/iep.12238.

Abstract

This study deals with the levels of toxic polychlorinated dibenzo-p-dioxin and furan congeners (PCDD/Fs) in the livers of piglets affected by infectious diseases using isotope dilution high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Seventeen toxic congeners in the liver samples infected with bacterial and viral diseases were compared. For porcine reproductive and respiratory syndrome virus (PRRSV) samples, the North American- and European-type PRRS diseases were observed. This study shows that there are significantly different levels of PCDD/Fs, present, which vary according to the types of diseases as evidenced by our analysis of the piglet liver samples.

Keywords: bacillus nature diseases; piglet; polychlorinated dibenzo-p-dioxins/furans; porcine reproductive and respiratory syndrome virus (PRRSV).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzofurans / pharmacology*
  • Chemical and Drug Induced Liver Injury
  • Liver / drug effects*
  • Mass Spectrometry / methods
  • Polychlorinated Dibenzodioxins / pharmacology*
  • Swine

Substances

  • Benzofurans
  • Polychlorinated Dibenzodioxins