Abstract
3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate. Graphene oxide nanoparticles (GO-np) have been used as a delivery vehicle for small molecule drugs in order to investigate the state of GO-np within 3D tissue constructs in terms of a composite 3D printing scaffold, which in turn is relevant to the protection of cartilage. We transplanted rats with hydrogel/GO-np and hydrogel, which in turn showed that hydrogel/GO-np protected the tissue of cartilage by the signal pathway of Rank/Rankl/OPG. Those findings indicated that GO-np may be potentially used to control the release of carrier materials and influence the signal pathway of Rank/Rankl/OPG.
Keywords:
3D printing; Chondrocytes; Graphene oxide; Rank.
Copyright © 2017 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Biocompatible Materials / chemistry*
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Biocompatible Materials / pharmacology
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Bone Morphogenetic Protein 7 / chemistry
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Bone Morphogenetic Protein 7 / metabolism
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Bone Morphogenetic Protein 7 / pharmacology
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Cartilage / drug effects
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Cartilage / metabolism*
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Cell Line
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Cell Survival / drug effects
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Chondrocytes / cytology
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Chondrocytes / drug effects
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Chondrocytes / metabolism
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Drug Carriers / chemistry
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Graphite / chemistry*
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Humans
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Hydrogels / chemistry*
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Male
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Nanoparticles / chemistry
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Osteoprotegerin / metabolism*
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Oxides / chemistry
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RANK Ligand / metabolism*
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Rats
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Rats, Sprague-Dawley
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Receptor Activator of Nuclear Factor-kappa B / metabolism*
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Signal Transduction / drug effects
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Tissue Scaffolds / chemistry
Substances
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Biocompatible Materials
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Bone Morphogenetic Protein 7
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Drug Carriers
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Hydrogels
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Osteoprotegerin
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Oxides
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RANK Ligand
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Receptor Activator of Nuclear Factor-kappa B
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Graphite