Regulating DNA Self-assembly by DNA-Surface Interactions

Longfei Liu; Yulin Li; Yong Wang; Jianwei Zheng; Chengde Mao

doi:10.1002/cbic.201700545

Regulating DNA Self-assembly by DNA-Surface Interactions

Chembiochem. 2017 Dec 14;18(24):2404-2407. doi: 10.1002/cbic.201700545. Epub 2017 Nov 9.

Authors

Longfei Liu¹, Yulin Li², Yong Wang^{1

3}, Jianwei Zheng⁴, Chengde Mao¹

Affiliations

¹ Purdue University, Department of Chemistry, West Lafayette, IN, 47906, USA.
² Hefei University of Technology, School of Chemistry and Chemical Engineering, Hefei, Anhui, 230009, China.
³ Nanchang University, College of Chemistry, Nanchang, Jiangxi, 330031, China.
⁴ Capital Medical University, Beijing Tiantan Hospital, Department of General Surgery, Beijing, 100050, China.

PMID: 29024338
DOI: 10.1002/cbic.201700545

Abstract

DNA self-assembly provides a powerful approach for preparation of nanostructures. It is often studied in bulk solution and involves only DNA-DNA interactions. When confined to surfaces, DNA-surface interactions become an additional, important factor to DNA self-assembly. However, the way in which DNA-surface interactions influence DNA self-assembly is not well studied. In this study, we showed that weak DNA-DNA interactions could be stabilized by DNA-surface interactions to allow large DNA nanostructures to form. In addition, the assembly can be conducted isothermally at room temperature in as little as 5 seconds.

Keywords: DNA-surface interactions; nanostructures; nanotechnology; self-assembly.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

DNA / metabolism*
Kinetics
Microscopy, Atomic Force
Nanostructures / chemistry*
Nanotechnology / methods
Nickel / chemistry
Surface Properties

Substances

Nickel
DNA