C-H Functionalisation for Hydrogen Isotope Exchange

Jens Atzrodt; Volker Derdau; William J Kerr; Marc Reid

doi:10.1002/anie.201708903

C-H Functionalisation for Hydrogen Isotope Exchange

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3022-3047. doi: 10.1002/anie.201708903. Epub 2018 Feb 2.

Authors

Jens Atzrodt¹, Volker Derdau¹, William J Kerr², Marc Reid²

Affiliations

¹ Isotope Chemistry and Metabolite Synthesis, Integrated Drug Discovery, Medicinal Chemistry, Industriepark Höchst, G876, 65926, Frankfurt, Germany.
² Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, G1 1XL, UK.

PMID: 29024330
DOI: 10.1002/anie.201708903

Abstract

The various applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demand a range of methods for their installation in an array of molecular architectures. In this Review, we describe recent advances in synthetic C-H functionalisation for hydrogen isotope exchange.

Keywords: C−H functionalization; catalysis; drug discovery; hydrogen isotope exchange.

Publication types

Review
Research Support, Non-U.S. Gov't