Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases

PLoS One. 2017 Oct 12;12(10):e0185193. doi: 10.1371/journal.pone.0185193. eCollection 2017.

Abstract

Background: Gallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications.

Objectives: Identifying risk factors for gallstones and kidney stones in IBD patients.

Methods: Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of diseases characteristics with gallstones and kidney stones in univariate and multivariate logistic regression analyses.

Results: Out of 2323 IBD patients, 104 (7.8%) Crohn's disease (CD) and 38 (3.8%) ulcerative colitis (UC) patients were diagnosed with gallstones. Significant risk factors for gallstones were diagnosis of CD, age at diagnosis, disease activity and duration, NSAID intake, extra-intestinal manifestations and intestinal surgery. Kidney stones were described in 61 (4.6%) CD and 30 (3.0%) UC patients. Male gender, disease activity, intestinal surgery, NSAID usage and reduced physical activity were significant risk factors. Hospitalization was associated with gallstones and kidney stones. The presence of gallstones increased the risk for kidney stones (OR 4.87, p<0.001).

Conclusion: The diagnosis of CD, intestinal surgery, prolonged NSAID use, disease activity and duration and bowel stenosis were significantly associated with cholecystonephrolithiasis in IBD.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Female
  • Gallstones / epidemiology*
  • Gallstones / etiology
  • Hospitalization
  • Humans
  • Incidence
  • Inflammatory Bowel Diseases / complications*
  • Kidney Calculi / epidemiology*
  • Kidney Calculi / etiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Switzerland / epidemiology
  • Time Factors
  • Young Adult

Grants and funding

This work was supported by research grants from the Swiss National Science Foundation to BM [grant no. 32473B_156525], to MS [grant no. 314730-146204, grant no. 314730_166381 and grant no. CRSII3 154488/1] and the Swiss IBD Cohort [grant no. 3347CO-108792] to GR (www.snf.ch). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.