α-Glucosidase inhibitory and cytotoxic botryorhodines from mangrove endophytic fungus Trichoderma sp. 307

Nat Prod Res. 2018 Dec;32(24):2887-2892. doi: 10.1080/14786419.2017.1385023. Epub 2017 Oct 12.

Abstract

One new depsidone, botryorhodine H (1), together with three known analogues, botryorhodines C, D and G (2-4), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds 1-3 showed α-glucosidase inhibitory activity with IC50 ranging from 8.1 to 11.2 μM, and compound 1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC50 = 3.09 and 3.64 μM).

Keywords: sp; Botryorhodine H; cytotoxicity; endophytic fungus; α-glucosidase inhibitory activity.

MeSH terms

  • Acinetobacter / cytology
  • Animals
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Cell Line
  • Coculture Techniques
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Glycoside Hydrolase Inhibitors / therapeutic use
  • Inhibitory Concentration 50
  • Molecular Structure
  • Pituitary Neoplasms / drug therapy
  • Plant Extracts / chemistry
  • Polyketides / chemistry
  • Polyketides / isolation & purification
  • Prolactinoma / drug therapy
  • Rats
  • Trichoderma / chemistry*

Substances

  • Antineoplastic Agents
  • Glycoside Hydrolase Inhibitors
  • Plant Extracts
  • Polyketides