Dataset on the synthesis and characterization of boron fenbufen and its F-18 labeled homolog

Chun-Nan Yeh; Chi-Wei Chang; Yi-Hsiu Chung; Shi-Wei Tien; Yong-Ren Chen; Tsung-Wen Chen; Ying-Cheng Huang; Hsin-Ell Wang; You-Cheng Chou; Ming-Huang Chen; Kun-Chun Chiang; Wen-Sheng Huang; Chung-Shan Yu

doi:10.1016/j.dib.2017.08.048

Dataset on the synthesis and characterization of boron fenbufen and its F-18 labeled homolog

Data Brief. 2017 Sep 5:15:174-202. doi: 10.1016/j.dib.2017.08.048. eCollection 2017 Dec.

Authors

Chun-Nan Yeh¹, Chi-Wei Chang², Yi-Hsiu Chung³, Shi-Wei Tien⁴, Yong-Ren Chen⁴, Tsung-Wen Chen¹, Ying-Cheng Huang⁵, Hsin-Ell Wang⁶, You-Cheng Chou⁴, Ming-Huang Chen⁷, Kun-Chun Chiang⁸, Wen-Sheng Huang², Chung-Shan Yu^{4

9}

Affiliations

¹ Department of Surgery, Liver Research Center, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taiwan.
² Department of Nuclear Medicine, Veterans General Hospital at Taipei, Taiwan.
³ Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taiwan.
⁴ Department of Biomedical Engineering and Environmental Sciences, National Tsinghua University, Hsinchu 300, Taiwan.
⁵ Department of Neurosurgery, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taiwan.
⁶ Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
⁷ Department of Medical Radiology, Yang-Ming University at Taipei, Taiwan.
⁸ Department of Surgery, Chang-Gung Memorial Hospital at Keelung, Chang Gung University, Taiwan.
⁹ Institute of Nuclear Engineering and Science, National Tsing-Hua University, Hsinchu 300, Taiwan.

Abstract

The data presented in this article are related to the research article entitled "Synthesis and Characterization of Boron Fenbufen and its F-18 Labeled Homolog for Boron Neutron Capture Therapy of COX-2 Overexpressed Cholangiocarcinoma". The contents of the data article include 1) the set up for performing in vitro binding assay, 2) ¹H-, ¹³C- and ¹⁹F-NMR of compounds described in main text, 3) HPLC chromatogram of the fluorination mixtures, 4) data of in vitro stability test, cell survival assay, western blot and PCR analysis, 5) the modules for fixing the two CCA rats for BNCT, and 6) bar diagram for tumor reduction using [¹⁸F]FDG-PET 24 h post treatment with BNCT.

Keywords: Binding; Coupling constant; NMR spectra; Setup; Survival.