Genomic characterization of an extensively drug-resistant KPC-2-producing Klebsiella pneumoniae ST855 (CC258) only susceptible to ceftazidime-avibactam isolated in Brazil

Diagn Microbiol Infect Dis. 2017 Dec;89(4):324-327. doi: 10.1016/j.diagmicrobio.2017.08.017. Epub 2017 Aug 25.

Abstract

In this study, we describe the genetic features of an XDR KPC-2-producing Klebsiella pneumoniae isolate by using whole-genome sequencing, its clinical-epidemiological context and susceptibility against antimicrobial combinations. The isolate belongs to clonal complex 258 and harbors several acquired genes and mutations associated with antimicrobial resistance.

Keywords: Colistin resistance; Extensively drug-resistant; KPC-2; Klebsiella pneumoniae; XDR.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Azabicyclo Compounds / pharmacology*
  • Bacterial Proteins / genetics*
  • Brazil
  • Ceftazidime / pharmacology*
  • Chromosomes, Bacterial / genetics
  • Drug Combinations
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / isolation & purification
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Bacterial Proteins
  • Drug Combinations
  • avibactam, ceftazidime drug combination
  • Ceftazidime