Influenza A(H5N1) Virus Infection in a Child With Encephalitis Complicated by Obstructive Hydrocephalus

Clin Infect Dis. 2018 Jan 6;66(1):136-139. doi: 10.1093/cid/cix707.

Abstract

A 2-year-old boy with highly pathogenic avian influenza A(H5N1) virus infection with minimal respiratory symptoms developed encephalitis complicated by obstructive hydrocephalus. Viral RNA was detectable in cerebrospinal fluid. The virus belonged to H5N1 clade 2.3.2.1b and had acquired the mammalian adaptation mutation PB2 Q591K.

Keywords: H5N1; avian influenza; central nervous system infection; hydrocephalus.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Brain / diagnostic imaging
  • Brain / pathology
  • Cerebrospinal Fluid / virology
  • Child, Preschool
  • Encephalitis, Viral / complications
  • Encephalitis, Viral / diagnosis*
  • Encephalitis, Viral / pathology*
  • Humans
  • Hydrocephalus / diagnosis*
  • Hydrocephalus / pathology*
  • Influenza A Virus, H5N1 Subtype / classification
  • Influenza A Virus, H5N1 Subtype / genetics
  • Influenza A Virus, H5N1 Subtype / isolation & purification*
  • Influenza, Human / complications*
  • Influenza, Human / diagnosis
  • Influenza, Human / pathology
  • Influenza, Human / virology
  • Male
  • Mutation, Missense
  • RNA, Viral / cerebrospinal fluid
  • RNA-Dependent RNA Polymerase / genetics
  • Tomography, X-Ray Computed
  • Viral Proteins / genetics

Substances

  • PB2 protein, Influenzavirus A
  • RNA, Viral
  • Viral Proteins
  • RNA-Dependent RNA Polymerase