Noninvasive detection of focal brain hyperthermia related to continuous epileptic activities using proton MR spectroscopy

Daichi Sone; Naoki Ikegaya; Akio Takahashi; Kaoru Sumida; Miho Ota; Takashi Saito; Yukio Kimura; Hiroshi Matsuda; Noriko Sato

doi:10.1016/j.eplepsyres.2017.10.001

Noninvasive detection of focal brain hyperthermia related to continuous epileptic activities using proton MR spectroscopy

Epilepsy Res. 2017 Dec:138:1-4. doi: 10.1016/j.eplepsyres.2017.10.001. Epub 2017 Oct 6.

Authors

Daichi Sone¹, Naoki Ikegaya², Akio Takahashi³, Kaoru Sumida⁴, Miho Ota⁵, Takashi Saito⁶, Yukio Kimura⁷, Hiroshi Matsuda⁸, Noriko Sato⁹

Affiliations

¹ Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8654, Japan. Electronic address: daichisone@gmail.com.
² Department of Neurosurgery, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: nikegaya@ncnp.go.jp.
³ Department of Neurosurgery, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: akiotaka@ncnp.go.jp.
⁴ Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: sumida.cold@gmail.com.
⁵ Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: ota@ncnp.go.jp.
⁶ Department of Child Neurology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: stakashi@ncnp.go.jp.
⁷ Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: yukio-k01@ncnp.go.jp.
⁸ Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: matsudah@ncnp.go.jp.
⁹ Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: snoriko@ncnp.go.jp.

PMID: 29017073
DOI: 10.1016/j.eplepsyres.2017.10.001

Abstract

Recent studies using rat models suggested that epileptic discharges (EDs) can induce focal brain hyperthermia, but such ED-related hyperthermia has not been confirmed in humans. We examined hyperthermia of the focus of epilepsy using noninvasive proton magnetic resonance spectroscopy (¹H-MRS) thermometry. We recruited six pediatric patients with refractory daily seizures, continuous interictal epileptic discharges, and concordant focus lesions on MRI who had undergone comprehensive presurgical exams. ¹H-MRS thermometry calculated the temperatures of the presumed epileptogenic lesions, and we examined the contralateral counterparts in each patient as controls. As a result, the mean temperature of the epileptogenic foci (36.81°C) was significantly higher than that of the controls (36.01°C). The mean difference was 0.81°C (95%CI: 0.22-1.39, p=0.017). ¹H-MRS thermometry may have the ability to noninvasively detect focal brain hyperthermia related to continuous EDs in human subjects, and to contribute to a better understanding and focus detection of epilepsy.

Keywords: Brain temperature; Focal epilepsy; Focal hyperthermia; Magnetic resonance spectroscopy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain / diagnostic imaging*
Brain / physiopathology*
Child
Child, Preschool
Electroencephalography
Epilepsy / complications*
Female
Fever / diagnostic imaging*
Fever / etiology*
Humans
Infant
Magnetic Resonance Imaging
Male
Positron-Emission Tomography
Proton Magnetic Resonance Spectroscopy*
Retrospective Studies
Tomography, Emission-Computed, Single-Photon