Abstract
The efficacy of recombinant interferon γ (rIFN-γ) for cryptococcal meningoencephalitis has been poorly understood. Compared to Cryptococcus gattii, rIFN-γ significantly improved the survival in experimental meningoencephalitis due to Cryptococcus neoformans. The number of phagocytic macrophages and the levels of inflammatory cytokines production for ex vivo co-incubation with C. neoformans were increased after rIFN-γ stimulation but not C. gattii. Intraspecies differences of phagocytosis by the rIFN-γ-activated macrophages might be associated to the severity of cryptococcal infection.
MeSH terms
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Animals
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use
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Cell Line
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Colony Count, Microbial
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Cryptococcus gattii / drug effects
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Cryptococcus gattii / pathogenicity
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Cryptococcus neoformans / drug effects
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Cryptococcus neoformans / pathogenicity
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Disease Models, Animal
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Female
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Interferon-gamma / pharmacology
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Interferon-gamma / therapeutic use*
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Macrophages / cytology
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Macrophages / drug effects*
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Macrophages / metabolism
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Meningoencephalitis / drug therapy*
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Meningoencephalitis / microbiology
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Meningoencephalitis / mortality
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Meningoencephalitis / pathology
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Mice
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Mice, Inbred C57BL
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Phagocytosis / drug effects
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Species Specificity
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Survival Rate
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Virulence
Substances
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Antifungal Agents
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Interferon-gamma