Role of CYP3A in Oral Contraceptives Clearance

Clin Transl Sci. 2018 May;11(3):251-260. doi: 10.1111/cts.12499. Epub 2017 Oct 6.

Authors

Nan Zhang^{1

2}, Jihong Shon¹, Myong-Jin Kim¹, Chongwoo Yu¹, Lei Zhang¹, Shiew-Mei Huang¹, LaiMing Lee¹, Doanh Tran¹, Li Li¹

Affiliations

¹ Office of Clinical Pharmacology (OCP), Office of Translational Sciences (OTS), Center for Drug Evaluation and Research (CDER), US Food and Drug Administration (FDA), Silver Spring, Maryland, USA.
² Oak Ridge Institute for Science and Education (ORISE), Tennessee, Oak Ridge, USA.

No abstract available

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Administration, Oral
Contraceptives, Oral, Combined / pharmacokinetics*
Cytochrome P-450 CYP3A / metabolism*
Cytochrome P-450 CYP3A Inducers / pharmacology
Cytochrome P-450 CYP3A Inhibitors / pharmacology
Female
Humans
Liver / metabolism*
Metabolic Clearance Rate / drug effects*

Substances

Contraceptives, Oral, Combined
Cytochrome P-450 CYP3A Inducers
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 CYP3A