Three novel neo-clerodane diterpenoids Sheareria A-C (1-3) together with three known triterpenoid saponins were isolated from the whole herb of Sheareria nana S. Moore. Their structures were established by spectroscopic and chemical method. This is the first natural sulfated neo-clerodane diterpenoids. This is the first report of all these compounds from this plant. These neo-clerodane diterpenoids and triterpenoid saponins from S. nana S. Moore may be considered as chemotaxonomic markers for the genus. The compounds isolated were evaluated for their cytotoxic effects against three cancer cell lines, the test substances demonstrated selectivity toward the cancer cells. To date, this is the first report on the phytochemical and biological activity of secondary metabolites from S. nana S. Moore.
Keywords: Chemotaxonomic; Neo-clerodane diterpenoid; Sheareria nana S. Moore; Sulfated; Triterpenoid saponin; asterlingulatoside C (PubChemCID: 44566668); astersaponins A (PubChemCID: 102321343); etoposide (PubChemCID: 36462); solidagoic acids C (PubChemCID: 101501878); solidagoic acids I (PubChemCID: 46177935).
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