Long-Read Sequencing Reveals a GC Pressure during the Evolution of Porcine Endogenous Retrovirus

Attila Szűcs; Norbert Moldován; Dóra Tombácz; Zsolt Csabai; Michael Snyder; Zsolt Boldogkői

doi:10.1128/genomeA.01040-17

Long-Read Sequencing Reveals a GC Pressure during the Evolution of Porcine Endogenous Retrovirus

Genome Announc. 2017 Oct 5;5(40):e01040-17. doi: 10.1128/genomeA.01040-17.

Authors

Attila Szűcs¹, Norbert Moldován¹, Dóra Tombácz^{1

2}, Zsolt Csabai¹, Michael Snyder², Zsolt Boldogkői³

Affiliations

¹ Department of Medical Biology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
² Department of Genetics, School of Medicine, Stanford University, Stanford, California, USA.
³ Department of Medical Biology, Faculty of Medicine, University of Szeged, Szeged, Hungary boldogkoi.zsolt@med.u-szeged.hu.

Abstract

Here, we present the complete genome sequence of a porcine endogenous retrovirus determined by Pacific Biosciences sequencing. A comparison of the genome of this isolate with those of other strains revealed the operation of a mechanism resulting in the selective accumulation of G and C bases in the viral DNA.

Grants and funding

P50 HG007735/HG/NHGRI NIH HHS/United States