Chemoradiotherapy for Solitary Skeletal Muscle Metastasis from Oesophageal Cancer: Case Report and Brief Literature Review

Yoshiaki Fujimoto; Yuichiro Nakashima; Shun Sasaki; Tomoko Jogo; Kosuke Hirose; Keitaro Edahiro; Shotaro Korehisa; Daisuke Taniguchi; Kensuke Kudou; Y U Nakaji; Ryota Nakanishi; Koji Ando; Hiroshi Saeki; Eiji Oki; Minako Fujiwara; Yoshinao Oda; Yoshihiko Maehara

doi:10.21873/anticanres.12005

Chemoradiotherapy for Solitary Skeletal Muscle Metastasis from Oesophageal Cancer: Case Report and Brief Literature Review

Anticancer Res. 2017 Oct;37(10):5687-5691. doi: 10.21873/anticanres.12005.

Authors

Yoshiaki Fujimoto¹, Yuichiro Nakashima¹, Shun Sasaki¹, Tomoko Jogo¹, Kosuke Hirose¹, Keitaro Edahiro¹, Shotaro Korehisa¹, Daisuke Taniguchi¹, Kensuke Kudou¹, Y U Nakaji^{1

2}, Ryota Nakanishi¹, Koji Ando¹, Hiroshi Saeki¹, Eiji Oki¹, Minako Fujiwara², Yoshinao Oda², Yoshihiko Maehara³

Affiliations

¹ Department of Surgery and Science, Graduate School of Medical Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
² Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
³ Department of Surgery and Science, Graduate School of Medical Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan maehara@surg2.med.kyushu-u.ac.jp.

PMID: 28982887
DOI: 10.21873/anticanres.12005

Abstract

Background: The incidence of skeletal muscle metastasis from oesophageal cancer is very low, and the treatment strategy has not been established.

Case report: A 77-year-old man underwent oesophagectomy following neoadjuvant chemotherapy for oesophageal squamous cell carcinoma (CT-pT3 N0 M0, CT-pStage II). Fourteen months after surgery, he became aware of a subcutaneous tumour in his left forearm. Computed tomography and fluorodeoxyglucose positron-emission tomography revealed a 65×75 mm intramuscular nodular lesion with a standardized uptake value of 8.5. Further examination by biopsy strongly suggested this was a solitary metastasis from oesophageal cancer. The patient received chemoradiotherapy with two cycles of 5-fluorouracil combined with cisplatin and radiation. Clinical complete response was confirmed by imaging 7 months after chemoradiation and no recurrence has occurred at 20 months since chemoradiation.

Conclusion: Radiotherapy or chemoradiotherapy can be an alternative locoregional therapy to surgery for solitary skeletal muscle metastasis.

Keywords: Oesophageal cancer; case report; chemoradiotherapy; skeletal muscle metastasis.

Publication types

Case Reports
Review

MeSH terms

Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Biomarkers, Tumor / analysis
Biopsy
Carcinoma, Squamous Cell
Chemoradiotherapy*
Cisplatin / administration & dosage
Esophageal Neoplasms / pathology*
Esophageal Squamous Cell Carcinoma
Fluorouracil / administration & dosage
Forearm
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Male
Muscle Neoplasms / chemistry
Muscle Neoplasms / secondary*
Muscle Neoplasms / therapy*
Muscle, Skeletal / chemistry
Muscle, Skeletal / pathology*
Neoplasm Staging
Neoplasms, Squamous Cell / chemistry
Neoplasms, Squamous Cell / secondary*
Neoplasms, Squamous Cell / therapy*
Positron-Emission Tomography
Time Factors
Treatment Outcome

Substances

Biomarkers, Tumor
Cisplatin
Fluorouracil