Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis

Sébastien Boutin; Simon Y Graeber; Mirjam Stahl; A Susanne Dittrich; Marcus A Mall; Alexander H Dalpke

doi:10.1183/13993003.01086-2017

Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis

Eur Respir J. 2017 Oct 5;50(4):1701086. doi: 10.1183/13993003.01086-2017. Print 2017 Oct.

Authors

Sébastien Boutin^{1

2}, Simon Y Graeber^{2

3

4}, Mirjam Stahl^{2

3

4}, A Susanne Dittrich^{2

4

5}, Marcus A Mall^{2

3

4

6}, Alexander H Dalpke^{7

2

6}

Affiliations

¹ Dept of Infectious Disease, Medical Microbiology and Hygiene, University Hospital Heidelberg, Germany.
² Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.
³ Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Dept of Pediatrics, University of Heidelberg, Heidelberg, Germany.
⁴ Dept of Translational Pulmonology, University of Heidelberg, Heidelberg, Germany.
⁵ Dept of Pneumology and Critical Care Medicine, Thoraxklinik at the University Hospital Heidelberg, Heidelberg, Germany.
⁶ Contributed equally as senior authors.
⁷ Dept of Infectious Disease, Medical Microbiology and Hygiene, University Hospital Heidelberg, Germany alexander.dalpke@med.uni-heidelberg.de.

PMID: 28982777
DOI: 10.1183/13993003.01086-2017

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Child
Cystic Fibrosis / microbiology*
Female
Humans
Lung* / microbiology
Lung* / pathology
Lung* / physiopathology
Male
Microbial Consortia
Microbial Interactions
Microbiota / physiology*
Patient Acuity
Pseudomonas Infections* / diagnosis
Pseudomonas Infections* / physiopathology
Pseudomonas aeruginosa* / pathogenicity
Pseudomonas aeruginosa* / physiology
Sputum / microbiology*