Dynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar-containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological aliphatic dialdehyde and a nonbiological aromatic dialdehyde. By using the saccharide-based dialdehyde, the biocompatibility of biodynamers should be enhanced compared to previously reported biodynamers.
Keywords: biodynamers; dynamic proteoids; equilibrium polymerization; nanostructures; supramolecular chemistry.
© 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.