2 IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo 24126, Italy; Unit of Nephrology and Dialysis, Department of Medicine, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. Electronic address: giuseppe.remuzzi@marionegri.it.