Super enhancers - new analyses and perspectives on the low hanging fruit

Feda H Hamdan; Steven A Johnsen

doi:10.1080/21541264.2017.1372044

Super enhancers - new analyses and perspectives on the low hanging fruit

Transcription. 2018;9(2):123-130. doi: 10.1080/21541264.2017.1372044. Epub 2017 Nov 3.

Authors

Feda H Hamdan¹, Steven A Johnsen¹

Affiliation

¹ a Department of General, Visceral and Pediatric Surgery , University Medical Center Göttingen , Göttingen , Germany.

Abstract

Significant attention has recently been given to a class of enhancers termed "super enhancers", while implying that "typical enhancers" are less important. In this report, we examine criteria for identification of super enhancers and address the need to evaluate the differences between BRD4-occupied "typical" and "super" enhancers.

Keywords: BRD4; ERα activation; ROSE algorithm; enhancer RNA; super enhancers; transcriptional regulation; typical enhancers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Cell Cycle Proteins
Enhancer Elements, Genetic*
Genomics
Humans
Models, Genetic
Nuclear Proteins / genetics
Nuclear Proteins / metabolism*
RNA / genetics
RNA / metabolism
Transcription Factors / genetics
Transcription Factors / metabolism*
Transcription, Genetic
Transcriptional Activation*

Substances

BRD4 protein, human
Cell Cycle Proteins
Nuclear Proteins
Transcription Factors
RNA

Grants and funding

Deutsche Krebshilfe [111600]; German Ministry for Science and Education (BMBF) [01KU1401A]; Deutsche Krebshilfe (PiPAC Consortium) [70112505]; Deutsche Forschungsgemeinschaft (DFG) [JO 815/3-1].