The novel HLA-B*08:183 allele identified by sequence-based typing in a Caucasian leukemia patient

HLA. 2017 Dec;90(6):367-368. doi: 10.1111/tan.13151. Epub 2017 Oct 10.

Abstract

HLA-B*08:183 differs from HLA-B*08:01:01 by a single substitution in exon 5.

Keywords: HLA-B novel variant; hematopoietic stem cells; human leukocyte antigen; new allele; sequence-based typing.

MeSH terms

  • Alleles*
  • Amino Acid Substitution
  • Base Sequence
  • Codon / chemistry
  • Exons*
  • Gene Expression
  • HLA-B8 Antigen / genetics*
  • HLA-B8 Antigen / immunology
  • Haplotypes
  • Hematopoietic Stem Cell Transplantation
  • Histocompatibility Testing
  • Humans
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Sequence Analysis, DNA
  • Transplant Recipients*
  • White People

Substances

  • Codon
  • HLA-B8 Antigen