Synthesis of Some New Tetrahydropyrimidine Derivatives as Possible Antibacterial Agents

Naser Foroughifar; Somayeh Karimi Beromi; Hoda Pasdar; Masoumeh Shahi

Synthesis of Some New Tetrahydropyrimidine Derivatives as Possible Antibacterial Agents

Iran J Pharm Res. 2017 Spring;16(2):596-601.

Authors

Naser Foroughifar¹, Somayeh Karimi Beromi¹, Hoda Pasdar¹, Masoumeh Shahi¹

Affiliation

¹ Department of Chemistry, Tehran North Branch, Islamic Azad University, Tehran, Iran.

PMID: 28979312
PMCID: PMC5603867

Abstract

Heterocyclic compounds containing a pyrimidine nucleus are of special interests thanks to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine derivatives (1-10) were synthesized via Biginelli reaction using HCl or DABCO as a catalyst with good yields. All structures of products were confirmed by IR, ¹H NMR and ¹³C NMR spectroscopy. The antibacterial activity of some synthesized compounds was investigated against Staphylococcusaureus (ATCC 6538), Staphylococcus epidermidis (ATCC 12228),Bacillus cereus (ATCC14579), Esherichia coli (ATCC 25922), Klebsiella pneumonia (ATCC 13883) and Pseudomonas aeruginosa (PAO1) bacteria. Some of these compounds such as 8 and 10 exhibited a good to significant antibacterial activity.

Keywords: Biginelli reaction; Tetrahydropyrimidine; antimicrobial activity.