Pathways to understanding the genomic aetiology of osteoarthritis

Elena Cibrián Uhalte; Jeremy Mark Wilkinson; Lorraine Southam; Eleftheria Zeggini

doi:10.1093/hmg/ddx302

Pathways to understanding the genomic aetiology of osteoarthritis

Hum Mol Genet. 2017 Oct 1;26(R2):R193-R201. doi: 10.1093/hmg/ddx302.

Authors

Elena Cibrián Uhalte¹, Jeremy Mark Wilkinson², Lorraine Southam^{3

4}, Eleftheria Zeggini⁴

Affiliations

¹ Human Genetics and Cellular Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
² Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2RX, UK.
³ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
⁴ Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

Abstract

Osteoarthritis is a common, complex disease with no curative therapy. In this review, we summarize current knowledge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping catalyse a much-needed improved understanding of the biological underpinning of disease development and progression.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Disease Progression
Genomics / methods
Humans
Osteoarthritis / etiology*
Osteoarthritis / genetics*
Risk Factors
Synovial Fluid / physiology