Usutu virus in cerebrospinal fluid: A 2-year survey in a Tertiary Care Hospital, Geneva, Switzerland

J Med Virol. 2018 Mar;90(3):609-611. doi: 10.1002/jmv.24967. Epub 2017 Nov 9.

Abstract

In 2009, the Usutu virus (USUV) was first reported as a cause of human neuroinvasive disorders. In Switzerland, USUV has been detected in wild birds with a seroprevalence of up to 6.59% in captive specimens sampled from zoo enclosures. This study investigates the clinical prevalence of USUV in human acute neuroinvasive disorders in Switzerland. Two hundred and fifty-eight cerebrospinal fluid samples collected between 2015 and 2017 for routine clinical care in a tertiary level hospital (Geneva) were tested for USUV by rRT-PCR. No samples were found positive, suggesting the absence, or the extremely low circulation of USUV in Western Switzerland.

Keywords: Switzerland; Tertiary Care Hospital; Usutu virus; cerebrospinal fluid; survey.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Child
  • Child, Preschool
  • Cohort Studies
  • Encephalitis, Viral / cerebrospinal fluid
  • Encephalitis, Viral / epidemiology
  • Flavivirus / genetics
  • Flavivirus / isolation & purification*
  • Flavivirus Infections / cerebrospinal fluid*
  • Flavivirus Infections / epidemiology
  • Humans
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Nervous System Diseases / epidemiology
  • Nervous System Diseases / virology*
  • Pilot Projects
  • RNA, Viral / genetics
  • Real-Time Polymerase Chain Reaction
  • Switzerland / epidemiology
  • Tertiary Care Centers
  • Young Adult

Substances

  • RNA, Viral

Supplementary concepts

  • Usutu virus