Development of Hyperkinesias after Long-term Pallidal Stimulation for Idiopathic Segmental Dystonia

Andreas Wloch; Christian Blahak; Mahmoud Abdallat; Hans E Heissler; Marc E Wolf; Joachim K Krauss

doi:10.7916/D8V416KN

Development of Hyperkinesias after Long-term Pallidal Stimulation for Idiopathic Segmental Dystonia

Tremor Other Hyperkinet Mov (N Y). 2017 Sep 19:7:480. doi: 10.7916/D8V416KN. eCollection 2017.

Authors

Andreas Wloch¹, Christian Blahak², Mahmoud Abdallat¹, Hans E Heissler¹, Marc E Wolf², Joachim K Krauss¹

Affiliations

¹ Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
² Department of Neurology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.

Abstract

Background: Chronic deep brain stimulation (DBS) of the globus pallidus internus (GPi) has become an established treatment for dystonia. While bradykinetic symptoms may occur on chronic stimulation, the appearance of hyperkinetic movements has not been well characterized.

Case report: We report on the development of hyperkinesias after more than 10 years of GPi DBS.

Discussion: Hyperkinesias may evolve upon long-term GPi DBS in dystonia. This might be related to a combined effect consisting of a reduced threshold for effective GPi stimulation for dystonia and spread of current to the globus pallidus externus.

Keywords: Deep brain stimulation; dystonia; globus pallidus; hyperkinesias; long term.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Deep Brain Stimulation / adverse effects*
Deep Brain Stimulation / methods
Dystonic Disorders / physiopathology
Dystonic Disorders / therapy*
Globus Pallidus* / physiopathology
Humans
Hyperkinesis / etiology*
Hyperkinesis / physiopathology
Male