Assessment of the quality of life (QOL) in modern medicine takes an important role, and can also provide a comprehensive evaluation of the patient's health status. The article presents the data of our own research evaluating the QOL of patients after cholecystectomy for a period of 0.7 to 4.1 years. The patients were interviewed using the international questionnaire - GastrointestinalQualityofLifeIndex (GIQLI). QOLs were evaluated depending on factors such as postoperative time, type of hospitalization, sex, age, marital status, changes in the gallbladder structure, activity, duration of hospitalization, and the type of surgical access. As a result of the research, it was determined that the increase in the QOL index correlates with the period elapsed since the surgery. Positive effects on QOL were influenced by such factors as patients' staying with the family, the planned of cholecystectomy (vs. urgent surgery), laparatomic surgical access, age and sex. QOL also proved to be higher in patients with chronic changes in the gallbladder.