Abstract
A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly identified mcr-3, and a carbapenemase gene, blaNDM-5mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by a TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.
Keywords:
Enterobacteriaceae; Escherichia coli; colistin; plasmids; resistance.
Copyright © 2017 American Society for Microbiology.
MeSH terms
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Amino Acid Substitution
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Anti-Bacterial Agents / pharmacology
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Colistin / pharmacology
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DNA Transposable Elements
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Drug Resistance, Multiple, Bacterial / genetics*
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Escherichia coli / drug effects
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Escherichia coli / enzymology
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Escherichia coli / genetics*
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Escherichia coli / isolation & purification
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Escherichia coli Infections / microbiology
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Escherichia coli Proteins / genetics*
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Escherichia coli Proteins / metabolism
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Gene Expression Regulation, Bacterial*
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Humans
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Microbial Sensitivity Tests
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Mutation
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Plasmids / chemistry
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Plasmids / metabolism
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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DNA Transposable Elements
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Escherichia coli Proteins
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MCR-1 protein, E coli
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Protein Isoforms
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beta lactamase NDM-5, E coli
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beta-Lactamases
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Colistin