Abstract
Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry. This review presents a detailed overview on the synthesis, QSAR and pharmacological applications of pyrazole. In addition, it covers most recent reports on structural modifications on pyrazole illustrating vital structural activity relationship.
Keywords:
Combinatorial chemistry; QSAR; medicinal chemistry; pharmacological activity; pharmacophore; pyrazole..
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MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Obesity Agents / chemical synthesis
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Humans
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Neoplasms / drug therapy*
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Obesity / drug therapy
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Quantitative Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Anti-Obesity Agents
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Antineoplastic Agents
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Antioxidants
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Enzyme Inhibitors
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Pyrazoles
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pyrazole