An HLA-D region restriction fragment associated with refractory Behçet's disease

Am J Ophthalmol. 1988 May 15;105(5):528-33. doi: 10.1016/0002-9394(88)90246-2.

Abstract

We examined the association between HLA-DQ and refractory Behçet's disease at the genomic DNA level. Using a restriction endonuclease Taq I and a DQ beta cDNA probe, we identified the 1.9 kb DQ beta restriction endonuclease fragment tightly associated with refractory Behçet's disease. This observation indicates that genomic HLA-DQ variations affect the development of refractory Behçet's disease.

MeSH terms

  • Behcet Syndrome / genetics
  • Behcet Syndrome / immunology*
  • DNA
  • HLA-D Antigens / genetics*
  • HLA-DQ Antigens / genetics
  • Humans
  • Nucleic Acid Hybridization
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length*

Substances

  • HLA-D Antigens
  • HLA-DQ Antigens
  • DNA