The objective of this study is to use weak acid cation exchange resin to mask the taste and eliminate the teeth staining problems of ferrous sulfate liquid preparations for use in pediatrics. Amberlite IPR64 was loaded by Fe(II). Then, different suspensions of the iron-resin complex were prepared using various polymers as the suspending agents, and sorbitol as well as sucrose as sweeteners. Physical stability, rheological assessment, kinetics of Fe(II) release, and taste evaluation of suspensions were studied. The results implied that the prepared iron suspension was more stable when xanthan gum is used as the suspending agent. It was also shown that iron release in 0.7% NaCl (similar to saliva) was very negligible compared to relatively quick release in acidic medium (resembled the stomach). Overall, the volunteers confirmed that the formulations were successful in iron taste masking. The pH-dependent process of ion exchange by weak cationic resins opens an attractive approach to access a taste-masked iron suspension for infants.
Keywords: Eudragit E100; iron; suspension; taste masking; weak cationic exchange resin.