Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry

Daniel J Tward; Chelsea S Sicat; Timothy Brown; Arnold Bakker; Michela Gallagher; Marilyn Albert; Michael Miller

doi:10.1016/j.dadm.2017.07.005

Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry

Alzheimers Dement (Amst). 2017 Sep 14:9:41-50. doi: 10.1016/j.dadm.2017.07.005. eCollection 2017.

Authors

Daniel J Tward^{1

2}, Chelsea S Sicat¹, Timothy Brown¹, Arnold Bakker³, Michela Gallagher⁴, Marilyn Albert⁵, Michael Miller^{1

2

6}

Affiliations

¹ Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
² Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
³ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
⁴ Department of Psychological and Brain Sciences, Johns Hopkins School of Arts and Sciences, Baltimore, MD, USA.
⁵ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁶ Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.

Abstract

Introduction: Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease.

Methods: Here, we study this region in subjects with mild cognitive impairment (n = 36) and in control subjects (n = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time.

Results: We find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing.

Discussion: This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.

Keywords: Braak staging; Diffeomorphometry; Entorhinal cortex; Longitudinal analysis; Mild cognitive impairment; Shape analysis.

Abstract

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