SAMHD1 Sheds Moonlight on DNA Double-Strand Break Repair

Trends Genet. 2017 Dec;33(12):895-897. doi: 10.1016/j.tig.2017.09.007. Epub 2017 Sep 29.

Abstract

SAMHD1 (sterile α motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks (DSBs) by promoting recruitment of C-terminal binding protein interacting protein (CTIP), a DNA-end resection factor, to damaged DNA. These findings could benefit anticancer treatment.

Keywords: CTIP; DNA double-strand breaks; DNA-end resection; SAMHD1; cancer; homologous recombination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Oxidoreductases / genetics
  • DNA / genetics*
  • DNA Breaks, Double-Stranded
  • DNA Repair / genetics*
  • DNA-Binding Proteins / genetics
  • Homologous Recombination / genetics
  • Humans
  • Nuclear Proteins / genetics
  • Protein Binding / genetics
  • SAM Domain and HD Domain-Containing Protein 1 / genetics*

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • DNA
  • Alcohol Oxidoreductases
  • C-terminal binding protein
  • SAM Domain and HD Domain-Containing Protein 1