Phytochemicals to optimize cognitive function for military mission-readiness: a systematic review and recommendations for the field

Nutr Rev. 2017 Jun 1;75(suppl_2):49-72. doi: 10.1093/nutrit/nux005.

Abstract

Context: Optimizing cognitive performance and preventing cognitive impairments that result from exposure to high-stress situations are important to ensure mission-readiness for military personnel.

Objective: This systematic review assesses the quality of the evidence for plant-based foods and beverages, or their phytochemical constituents, across various outcomes related to cognitive function in healthy adult populations to develop research recommendations for the military.

Data sources: PubMed, CINAHL, Embase, PsycInfo, and the Cochrane Library were searched.

Study selection: Peer-reviewed randomized controlled trials published in the English language were eligible.

Data extraction: Twenty-five trials were included and assessed for methodological quality, and descriptive data were extracted.

Data synthesis: The acceptable (n = 16) to high-quality (n = 4) studies produced either no statistically significant effect or mixed results for enhancing cognitive function.

Conclusions: The evidence suggested that healthy populations do not experience significant changes in cognitive performance when consuming soy- and non-soy-sourced isoflavones or cocoa. Heterogeneity among other interventions precluded reaching formal conclusions surrounding the evidence. Research recommendations are offered, including conducting more studies on the effect of plant-based interventions on populations reflective of military populations when exposed to military-like situations.

Keywords: cocoa; cognitive brain function; diet; healthy; isoflavones; military; mission-readiness; phytochemicals; soy; systematic review.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Cacao / chemistry
  • Cognition / drug effects*
  • Diet*
  • Glycine max / chemistry
  • Humans
  • Isoflavones / administration & dosage
  • Military Medicine*
  • Military Personnel*
  • Phytochemicals / administration & dosage*
  • Randomized Controlled Trials as Topic
  • Stress, Psychological / physiopathology

Substances

  • Isoflavones
  • Phytochemicals